Recent surveys suggest that up to 15% of the population is affected by vitamin B12 deficiency. It is particularly prevalent in the older population, with an incidence rate of approximately 40% due to changes in their digestive systems, as well as in strict vegans, since this vitamin is only available from natural animal products such as eggs, fish, and meat. Patients with pernicious anemia and other intestinal disorders also commonly develop vitamin B12 deficiency due to their inability to absorb small amounts of the vitamin.

In older adults at high cardiovascular risk, improving and enhancing the bioavailability of serum vitamin B12 correlates with better memory function, suggesting that the effects of vitamin B12 go beyond a mere nutritional requirement.

Cyanocobalamin, a synthetic form of vitamin B12, has become the primary mode of treatment for vitamin B12 deficiency since its isolation in 1948. Treatment is mainly administered orally or through injections. However, oral forms often present issues related to unpredictable absorption. Most people with vitamin B12 deficiencies are treated in primary care with intramuscular or deep subcutaneous injections, with some requiring lifelong monthly injections. Intramuscular administration usually necessitates a trip to a healthcare facility or a home visit from a health professional, making it less convenient for patients.

A new method of administration that overcomes the limitations of both injections and oral administration is highly necessary. Alternative routes include transdermal, buccal, rectal, and nasal administration. Among these, the transdermal route stands out due to its high patient compliance, ease of use, and large surface area for drug absorption.

Transdermal Drug Delivery Systems (TDDS) offer several advantages over traditional dosage forms, such as non-invasiveness, high patient compliance, and avoidance of gastrointestinal metabolism and liver elimination. However, transdermal delivery can be limited by the skin's outer barrier, the stratum corneum. Our unique transdermal agents have safely addressed this challenge.

A transdermal route for delivering cyanocobalamin and polyphenols holds great promise when enhancement techniques are applied. The inclusion of polyphenols in transdermal applications adds significant benefits.

Polyphenols are healthy compounds found in fruits, vegetables, herbs, and tea. These powerful antioxidants can improve brain health, digestion, and blood sugar levels, and may even combat cancer and inflammation. Our research suggests that a diet enriched in polyphenols could help regulate the blood epigenome. We speculate that this regulation is influenced not only by key epigenetic players like vitamin B12 but also by the enriched polyphenol content, which may further regulate one-carbon metabolism, potentially affecting autoimmune responses.

In addition to protecting the body from infections and diseases, the immune system produces antibodies that can help mitigate complex autoimmune disorders such as Type I diabetes, primary biliary cirrhosis, rheumatoid arthritis, and multiple sclerosis, among others. Polyphenols have been widely studied as viable alternative treatments to help manage autoimmune disorders. These compounds possess a wide range of pharmacological and therapeutic properties, including antioxidant and anti-inflammatory effects. As immunomodulatory agents, polyphenols are emerging as promising pharmaceutical tools for managing conditions like vitiligo, ulcerative colitis, and multiple sclerosis (MS).

The improved bioavailability of B12 in our patch, combined with the unique synergistic benefits of the polyphenols in our once-daily Penetrex lotion, is exactly what you've been waiting for. The wait is over! Use the attached order form or call us at 1-(877) 842-4827.